The Science

Male Pattern Hair Loss (MPHL) can follow a number of different patterns, but is usually characterised by hair initially thinning from the sides and front of the forehead (receding hairline) followed by a bald patch at the crown of the head (vertex). Gradually, the bald area increases in size and eventually many men are left with a narrow horseshoe-shaped band of hair around the back and sides of the head (1). Most pattern baldness is genetic and whilst there is some research demonstrating both parents contribute to hereditary hair loss, a man has a greater chance of experiencing the same pattern baldness as his father.

The onset of MPHL can begin in men as young as 25 years and although the rate of hair loss varies from individual to individual, with some men going completely bald in less than 5 years, for most men hair loss is a much slower process - gradually occurring over 15-25 years (2). We know that the trigger for hereditary hair loss is caused by a powerful hormone known as DHT.

DHT - The Major Cause of Male Pattern Baldness

DHT (Dihydrotestosterone) is a powerful metabolite of the ‘testosterone’ hormone and is 3 times more potent than the hormone itself! DHT is renowned for its role in causing male pattern baldness, prostate problems and has also been identified as the cause of some types of acne.

The mechanism by which DHT causes hair loss in men is still not fully understood, but it is thought that DHT causes miniaturization (shrinkage) of the hair follicle, resulting in a progressive decrease in width of the hair shaft until the scalp hair resembles ultra fine, fragile ‘downy’ hair or becomes non-existent.

Many trials have been carried out to assess whether certain environmental and stressful conditions may have an effect on human DHT levels. One such trial in the USA observed army recruits who suffered extended sleep deprivation: the trial concluded that extreme stress due to sleep deprivation (in fit males) was unlikely to elevate DHT levels.

Read the LA Science Hair Loss Triggers page for further information.